Endocrine Abstracts

Objectives: Evaluate the benefit of postsurgical radioactive iodine (RAI) in patients with differentiated thyroid cancer (DTC) at low to intermediate risk of recurrent disease in whom not routinary use of RAI is recommendedMethods: We retrospectively evaluated 1316 patients with DTC diagnosed between 2009-2015. ATA low (LR) and intermediate (IR) risk were included in the study (PTC: tumor size > 1 cm, microscopic extrathyroidal invasion, <5 micro...

Background: Graves’ ophthalmopathy (GO) is an autoimmune disease that affects particularly the retrobulbar soft tissues and represents the most common extrathyroidal manifestation of Graves’ disease (GD). Some studies suggest that GO in newly diagnosed patients in recent years has a trend towards a less severe clinical presentation, moreover we have no studies that focus the trend of clinical presentation of GO in the last decade on the population of our area.<p ...

Objective: Clarify mechanisms determining thyroid homeostasis during pregnancy at hypothalamic-pituitary level.Methods: Retrospective analysis of 251 pregnant women. 220/251 euthyroid without thyroxine therapy (Group 1), 31/251 thyroidectomized under thyroxine replacement therapy (Group 2). Patients under thyroxine replacement therapy with a TSH between 0.4 and 4.0 were included in the study. Patients with combined T3/T4 therapy were excluded.<p clas...

Background: Hashimoto’s thyroiditis (HT) is the most common autoimmune disease worldwide. Prevalence of celiac disease (CD) is higher in HT patients and HT is the most prevalent coexisting disease in CD patients. In the last years, interest about gluten free diet (GFD) has increased for its supposed extraintestinal anti-inflammatory effect, so many patients with HT initiate GFD on their own.Objectives: Aim of this meta-analysis is to examine all qua...

Background: Graves’ disease (GD) is an autoimmune disorder of thyroid gland and is the first cause of hyperthyroidism. Radioactive iodine (RAI) therapy is the most used second- line treatment after failure of anti-thyroid drugs. The optimal RAI’s activity to be administered may be predetermined or calculated. Whether the latter is better is still a matter of debate.Aim: To compare the risk of persistent hyperthyroidism in GD patients treated wi...

Background: Tyrosine kinase inhibitors (TKIs) are modern antineoplastic molecules widely used in the medical treatment of many cancers including iodine refractory differentiated thyroid carcer (DTC) and advanced medullary thyroid cancer (MTC). In patients with thyroid gland, TKIs frequently cause a destructive and/or autoimmune thyroiditis with consequent hypothyroidism. However, authors have reported unexpected TSH increase or hypothyroidism even in patients with total thyroi...